LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
نویسندگان
چکیده
منابع مشابه
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis.
Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At least eight different Atg8 orthologs belonging to two subfamilies (LC3 and GATE-16/GABARAP) occur in mammalian cells, but their individual roles and modes of action are largely unknown. In this study, we dissect the activ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2010
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2010.74